Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Query Trace: Abdul-Salaam S[original query] |
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Development of a method to estimate mouth-level benzo[a]pyrene intake by filter analysis
Ding Y , Chou T , Abdul-Salaam S , Hearn B , Watson CH . Cancer Epidemiol Biomarkers Prev 2011 21 (1) 39-44 BACKGROUND: Benzo[a]pyrene is one of the most potent carcinogens generated in cigarette smoke. During smoking, cigarette filters trap a significant portion of mainstream smoke benzo[a]pyrene. This trapped portion is proportional to what exits the end of the filter and is drawn into the smoker's mouth. METHODS: We developed a new method to estimate mouth-level benzo[a]pyrene intake using filter analysis. In this analysis, cigarettes are smoked by a smoking machine using a variety of conditions to yield a range of mainstream smoke deliveries, which approximate a range of human puffing characteristics. Mainstream smoke benzo[a]pyrene collected on Cambridge filter pads and the corresponding 1-cm mouth-end cigarette filter butts is extracted, purified by solid phase extraction, and quantified by high performance liquid chromatography coupled with a fluorescence detector. Based on the amount of benzo[a]pyrene retained in cigarette butts and the amount collected on pads, we can relate them using a linear regression model. RESULTS: Using this model and subsequently analyzing cigarette filters collected from smokers, we are able to estimate their mouth-level intakes, which smokers received when they consumed cigarettes. We made a series of measurements using research cigarettes and select commercial cigarettes having a wide range of machine smoke "tar" and nicotine deliveries. CONCLUSIONS: In all cases, results indicate a linear relation of benzo[a]pyrene between cigarette filter butts and Cambridge filter pads, with R2 ranging from 0.93 to 0.98. IMPACT: This technique provides a non-invasive means to examine intake on a per cigarette basis to examine both exposure and behavioral aspects of smoking. |
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